After 2000, Russian boreal forests have been lost due to major fire events and illegal loggings. The changes in the forests are rarely studied especially in the Far East region. Warmer records of average global temperature in recent years raise concern in the scientific community about its effect on climate change. Our study used remote sensing data such as Landsat images to monitoring and predict the vulnerability of forest cover change inside and outside of Zeya State Nature Reserve. Our study used a multi-criteria analysis model to generate a vulnerability map of forest disturbance. Our research found that forest disturbance occurred more severed outside the Reserve. Inside of the Reserve is very highly protected with no human-disturbance activity. The forest closer to the roads are found to be more susceptible to forest fire and clearcutting. Our findings provide supporting data that the Reserve is effective in terms of protecting its ecosystem but the forests outside the Reserve are vulnerable to disturbance. The study recommends scientists and park managers to focus on disturbance prevention not only inside of the Reserve but also along the human accessible path outside of the Reserve.